2,884 research outputs found

    Innovation dialogue - Being strategic in the face of complexity - Conference report

    Get PDF
    The Innovation Dialogue on Being Strategic in the Face of Complexity was held in Wageningen on 31 November and 1 December 2009. The event is part of a growing dialogue in the international development sector about the complexities of social, economic and political change. It builds on two previous events hosted the Innovation Dialogue on Navigating Complexity (May 2009) and the Seminar on Institutions, Theories of Change and Capacity Development (December 2008). Over 120 people attended the event coming from a range of Dutch and international development organizations. The event was aimed at bridging practitioner, policy and academic interests. It brought together people working on sustainable business strategies, social entrepreneurship and international development. Leading thinkers and practitioners offered their insights on what it means to "be strategic in complex times". The Dialogue was organized and hosted by the Wageningen UR Centre for Development Innovation working with the Chair Groups of Communication & Innovation Studies, Disaster Studies, Education & Competence Studies and Public Administration & Policy as co; organisers. The theme of the Dialogue aligns closely with Wageningen UR’s interest in linking technological and institutional innovation in ways that enable ‘science for impact’

    Journal Staff

    Get PDF
    This book constitutes the refereed proceedings of the 18th Scandinavian Conference on Image Analysis, SCIA 2013, held in Espoo, Finland, in June 2013. The 67 revised full papers presented were carefully reviewed and selected from 132 submissions. The papers are organized in topical sections on feature extraction and segmentation, pattern recognition and machine learning, medical and biomedical image analysis, faces and gestures, object and scene recognition, matching, registration, and alignment, 3D vision, color and multispectral image analysis, motion analysis, systems and applications, human-centered computing, and video and multimedia analysis

    Assessing the adaptation of arable farmers to climate change using DEA and bio-economic modelling

    Get PDF
    The objective of this article is to assess the impact of climate change on arable farming systems in Flevoland (the Netherlands) and to explore the adoption of different adaptation strategies. Data Envelopment Analysis (DEA) is applied that uses empirical data from individual farms to identify “best” current farm practices and derive relationships regarding current farm managemen

    Adapting agriculture in 2050 in Flevoland; perspectives from stakeholders

    Get PDF
    Although recently more research has gone into farm level studies, little attention has been given to the variety of responses of farmers, considering their characteristics, objectives and the socio-economic, technological and political contexts (Reidsma et al, 2010). In the Agri-Adapt project we focus on farm level adaptation within an agricultural region considering the socio-economic context of 2050

    PMI: A Delta Psi(m) Independent Pharmacological Regulator of Mitophagy

    Get PDF
    Mitophagy is central to mitochondrial and cellular homeostasis and operates via the PINK1/Parkin pathway targeting mitochondria devoid of membrane potential (ΔΨm) to autophagosomes. Although mitophagy is recognized as a fundamental cellular process, selective pharmacologic modulators of mitophagy are almost nonexistent. We developed a compound that increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy. The compound, P62-mediated mitophagy inducer (PMI), activates mitophagy without recruiting Parkin or collapsing ΔΨm and retains activity in cells devoid of a fully functional PINK1/Parkin pathway. PMI drives mitochondria to a process of quality control without compromising the bio-energetic competence of the whole network while exposing just those organelles to be recycled. Thus, PMI circumvents the toxicity and some of the nonspecific effects associated with the abrupt dissipation of ΔΨm by ionophores routinely used to induce mitophagy and represents a prototype pharmacological tool to investigate the molecular mechanisms of mitophagy

    Deprojection of luminosity functions of galaxies in the Coma cluster

    Full text link
    We use a simple analytic model to deproject 2-d luminosity functions (LF) of galaxies in the Coma cluster measured by Beijersbergen et al. 2002. We demonstrate that the shapes of the LFs change after deprojection. It is therefore essential to correct LFs for projection effects. The deprojected LFs of the central area have best-fitting Schechter parameters of M^{*}_U=-18.31^{+0.08}_{-0.08} and \alpha_U=-1.27^{+0.018}_{-0.018}, M^{*}_B=-19.79^{+0.14}_{-0.15} and \alpha_B=-1.44^{+0.016}_{-0.016} and M^{*}_r=-21.77^{+0.20}_{-0.28} and \alpha_r=-1.27^{+0.012}_{-0.012}. The corrections are not significant enough to change the previously observed trend of increasing faint end slopes with increasing distance to the cluster center. The weighted U, B, and r band slopes of the deprojected LFs show a slightly weaker steepening with increasing projected cluster radius.Comment: Accepted for publication in A&A as a Research Not

    Information systems for development planning

    Get PDF
    In this paper the changing approaches to development planning are described, from the economic-growth oriented strategies of the 1950s and the 1960s to the contemporary emphasis on alleviating poverty and meeting basic needs. The process of development planning includes several phases; the identification of aims, analysis, plan formulation and detailed design, Implementation, controls, updating, and feedback and adjustment. This process has become much more sophisticated in recent years, but in general, the comprehensiveness and refinement of a development plan depends on the type and scope of the data available. At the same time, the very process of planning may reveal deficiencies In data and thus act as an incentive to improved information gathering. Three information systems are needed for development planning: a resources information system, whose importance has been recognised for some time but which has frequently consisted of a series of isolated and uncoordinated inventories and studies; a scientific and technological information system' and a management information system, whose Importance has frequently been neglected. Information in these areas must be collected, communicated to government policy makers and administrators to meet their immediate needs, and stored in a convenient and coordinated form so that it will be accessible in the future. More global surveys and inventories will be needed during the eiarly stages of development planning, and detailed project and programme surveys will be needed during the design and implementation stages

    On the importance of aerosol nitrate over Europe : data analysis and modelling

    Get PDF
    The central theme of this thesis is the nitrate content of aerosols (or particulate matter (PM)). Aerosols play an important role in the climate system by scattering and/or absorbing solar radiation. In the last decades research has been devoted to quantify the radiative forcing of aerosols on climate. However, little is known about the forcing of aerosol nitrate. The large uncertainties around the nitrate forcing are directly related to a lack of reliable measurement data. In this thesis a study devoted to assess the importance of nitrate for the radiation balance over Europe is presented. The first step in this study was to search for data on aerosol nitrate. However, sampling aerosol nitrate is subject to evaporation losses and adsorption of nitric acid. Therefore, an analysis of sampling artefacts is presented first. Main results of this analysis are that quartz filters loose nitrate above 20ºC and that cellulose filters sample both nitrate and nitric acid quantitatively. Using the knowledge of artefacts we constructed a nitrate field over Europe for the winter. High nitrate levels are projected over north western, central and eastern Europe. There the nitrate concentrations exceed 4 µg/m3. Maximum levels are found in the Po valley. In Scandinavia nitrate levels trail off from 2.5 µg/m3 in the south to less than 0.5 µg/m3 in the north. In addition, we developed a chemistry-transport model (CTM) to describe the formation, dispersion and removal of nitrate and other aerosol components in the atmosphere. The model is able to reproduce the general features of the wintertime distribution derived from the observations. In winter nitric acid, the precursor for aerosol nitrate, is formed through heterogeneous reactions on the surface of aerosols. Appreciable ammonium nitrate concentrations in summer are limited to those areas with high ammonia emissions, e.g. the Netherlands. Over large parts of eastern and southern Europe low ammonium nitrate concentrations are modelled. Averaged over all stations the model reproduces the measured concentrations for NO3, SO4, NH4, TNO3, TNH4 and SO2 within 20%. Special attention is given to the uncertainty of the results towards ammonia emissions. A new emission database for black carbon (BC) and other primary aerosols was used to model the fine aerosol distribution over Europe. After sulphate, nitrate and carbonaceous aerosols are the most important contributors to the fine aerosol mass over Europe. The modelled concentrations for BC and total primary material are underestimated. An extended discussion on the discrepancy between model and observations for BC is presented. The nitrate fields over Europe, determined within this thesis, enable to estimate the radiative forcing by nitrate. Based on our simulations the annual forcing by nitrate is calculated to be 25 % of that by sulphate. In summer nitrate is found to be only regionally important, e.g. in the Netherlands, where the forcing of nitrate equals that by sulphate. In winter the nitrate forcing over Europe is about half the sulphate forcing. Overall, nitrate forcing is significant and should be taken into account to estimate the impact of regional climate change in Europe
    corecore